Secure your reservation on our site
Up to 10% less
than Booking.com
Check rooms and rates
From251US$ /night
Check-in
28Dec2025Select date
Check-out
29Dec2025Select date
Rooms and Guests2 Guests, 1 Room
Key details

Hotel overview and key features

167 West Main Street, Lexington, Kentucky, United States, 40507
-
Steps from Rupp Arena
Great
8.2
8.7
/10
4.5
4.2
/5

21C Museum Hotel Lexington, a 4-star hotel near Blue Grass Airport (9.3 miles away), occupies the historic Fayette National Bank Building in downtown Lexington. The property is within 0.3 miles of Triangle Park, Mary Todd Lincoln House, and Kentucky Theatre. Contemporary art exhibitions fill the 7000 square feet of gallery space throughout this boutique hotel.

Art-Infused Accommodations

Guest rooms at 21c Lexington feature custom-designed furnishings, Malin + Goetz bath amenities, and original artwork. Options include City Queen, Deluxe King, Deluxe Double Queen, and suites like the Skylight Suite with a separate living area. The Nightwatch room doubles as a fully immersive art installation by Chris Doyle.

Local Flavors Dining

Lockbox restaurant serves American cuisine with Kentucky-sourced ingredients, offering breakfast, dinner, and weekend brunch. The bar + lounge provides craft cocktails and seasonal menus influenced by local producers. Private dining is available in the restored bank safe room.

Art & Bourbon Experiences

21c Museum Hotel Lexington displays rotating contemporary art exhibitions across five private galleries. Guests can explore the Legacy Trail to Kentucky Horse Park or visit nearby distilleries like Castle & Key. The hotel hosts mocktail tours and cocktail classes like Cocktail, Savings & Booze.

Versatile Event Spaces

The property offers 7000 square feet of event space, including a Main Gallery for 250 guests. Business services include a 24-hour center and AV-equipped conference rooms for 12 attendees. Sustainable meeting options feature locally sourced catering from Lockbox's culinary team.

“I think 21c Museum Hotel Lexington distinguishes itself with its commitment to art and sustainability. The transformation of a historic bank building into a boutique hotel, complete with contemporary art installations and a restaurant emphasizing local ingredients, makes it a destination with substance. In my opinion, it's a great fit for those seeking a blend of culture, comfort, and eco-conscious hospitality.”
Hotel logo
Amelia BrooksLead Hotel Editor at Hotelairport
View all

Choose your ideal room style

Choose from family rooms, suites, flexible cancellation & more
City Queen Room
2 persons
22 m² 
1 King-size bed
Shower
Coffee machine
Deluxe Queen Room
2 persons
33 m² 
2 King Size Beds
Shower
Coffee machine
Deluxe King Room
2 persons
31 m² 
1 King-size bed
Shower
Coffee machine
Corner King Room
2 persons
40 m² 
1 King-size bed
Shower
Coffee machine
Click button to see more rooms
Show all rooms
Show all roomsLess

Prices and Availability

Check availability and prices for your travel dates right now!

Facilities

Stay relaxed and refreshed just minutes from the airport

General

  • No smoking on site
  • Free Wi-Fi in public areas
  • Safe deposit box
  • 24-hour reception
  • VIP check-in/ -out
  • Pets allowed
  • Rooms/ Facilities for disabled
  • 24-hour security
  • Luggage storage
  • Allergy-free rooms
  • Lift
  • ATM/Cash machine
  • Vending machines
  • Smoke detectors
  • Fire extinguishers
  • Key card access
  • Key access

Sports & Fitness

  • Fitness centre
  • Yoga class

Services

  • Paid shuttle service
  • Room service
  • Housekeeping
  • Laundry
  • Dry cleaning
  • Tours/Ticket assistance
  • Welcome drink

Dining

  • In-room breakfast
  • Restaurant
  • Snack bar
  • Bar/ Lounge area
  • Special diet menus

Business

  • Business centre
  • Meeting/ Banquet facilities
  • Fax/Photocopying

Children

  • Children's menu

Room features

  • Air conditioning
  • Heating
  • Soundproofed rooms
  • Sitting area
  • Dressing area
  • Tea and coffee facilities
  • Dining table
  • Ironing facilities

Bathroom

  • Free toiletries

Media

  • Flat-screen TV
  • AM/FM alarm clock
Show more

Dining Onsite

At 21C Museum Hotel Lexington, delightful dining options await, each offering a taste of local flavors. From creative American dishes to nostalgic family favorites, the onsite venues promise an inviting atmosphere where every meal is a celebration of authenticity.
21C Museum Hotel Lexington Restaurant photo

Lockbox

American, Local
Ambiance
A chic yet welcoming setting featuring modern decor, perfect for both casual breakfasts and intimate dinners.
Key Offerings
Highlighting seasonal ingredients with an array of vegetarian, vegan, gluten-free, and dairy-free choices, Lockbox serves breakfast and dinner with a menu that reflects the vibrant local palate.
Reservation
Recommended
Breakfast from 7 AM-11 AM, Dinner from 5 PM-10 PM (Sunday to Thursday) and till 11 PM on Saturday; check for specific hours on Sunday morning.

Location info

167 West Main Street, Lexington, Kentucky, United States, 40507
Map view
167 West Main Street, Lexington, Kentucky, United States, 40507
Nearby
430 West Vine Street
Rupp Arena
460 m
Museum
Hunt-Morgan House
460 m
Event hall
Lexington Convention Center
440 m
Theatre
Kentucky Theatre
360 m
440 W Short St
Explorium
450 m
University
University of Kentucky
90 m
Park
Triangle Park
340 m
Church
St Paul the Apostle Catholic Church
430 m
Library
Lexington Public Library Ceiling Clock and Foucault Pendulum
260 m
Shopping Area
Victorian Square Shoppes
340 m
Square
Phoenix Park
180 m
Gallery
Limestone Blue
130 m
Lexington Financial Center
Isaac Murphy Memorial Art Garden
140 m
Gallery
Pam Miller Downtown Arts Center
220 m
Gallery
ArtsPlace
240 m
7285 Huron Street
Huron Street Gallery
250 m
Gratz Park
490 m
Restaurants
Bourbon on Rye
70 m
115 W Main St
Corto Lima
180 m
101 West Short Street Corner of West Short and North Limestone Streets
School Sushi
120 m
163 West Short Street
Bluegrass Tavern
150 m
115 Cheapside
Horse And Jockey
190 m
131 Cheapside
Buddha Lounge
190 m
109 N Mill St
Explore Lexington
Explore Lexington
Top Attractions
Activities
Dining
Entertainment
Rupp Arena
Rupp Arena
6 minutes' walk
Home to the Kentucky Wildcats, this arena hosts sports events and concerts, making it a central hub for entertainment.
Thoroughbred Park
Thoroughbred Park
12 minutes' walk
This park celebrates Kentucky's horse racing history with beautiful sculptures and trails, ideal for a leisurely stroll.
Kentucky Theatre
Kentucky Theatre
5 minutes' walk
A historic venue featuring independent films and live events, this theater offers a charming glimpse into Lexington's cultural scene.
Mary Todd Lincoln House
Mary Todd Lincoln House
9 minutes' walk
The childhood home of Mary Todd Lincoln, this historic site provides guided tours showcasing her life and the era's history.
Horse Country Tours
12 minutes' walk
Guided tours through local horse farms offer thrilling insight into thoroughbred racing and Kentucky's equestrian culture.
Yoga at The Arboretum
15 minutes' drive
A serene outdoor setting for yoga classes, complete with beautiful landscapes. Booking in advance is recommended.
Bourbon on Rye
Bourbon on Rye
1 minute' walk
Casual American eatery focusing on bourbon-infused dishes. Reservations recommended for peak times.
Corto Lima
Corto Lima
3 minutes' walk
Offering a vibrant atmosphere and Latin cuisine, this restaurant is known for its fresh ingredients and creative cocktails.
WoodSongs Old-Time Radio Hour
WoodSongs Old-Time Radio Hour
10 minutes' walk
A weekly live music show featuring folk and roots music, perfect for music lovers of all ages in a laid-back setting.
Manchester Music Hall
Manchester Music Hall
15 minutes' walk
This venue hosts a variety of concerts and performances, creating an energetic nightlife atmosphere for guests.
Getting around
City Centre
Lexington5 min  ·  400 m
Airports
Blue Grass Airport (LEX)21 min  ·  13.7 km
Looking for early discounts?
Get airport hotel deals before everyone else
Check Rates
Property information and rules
Check-in
from 16:00-23:59
Check-out
until 11 am
Guest Parking
No parking available.
Internet
is available in public areas for free.
Children & extra beds
There are no extra beds provided in a room.  There are no cots provided in a room. 
Pets
Pets are allowed on request.
Number of floors:
15
Number of rooms:
85
FAQs
About 21C Museum Hotel Lexington
How far is 21C Museum Hotel Lexington from Blue Grass Airport?
The hotel is 9 km from Blue Grass Airport, which is approximately a 20-minute drive.
Is there parking available at 21C Museum Hotel Lexington?
The hotel offers on-site parking options, including valet parking, for an additional fee.
What dining options are available at 21C Museum Hotel Lexington?
The hotel features an on-site restaurant called Lockbox, which specializes in seasonal menus made with local ingredients.
What are the check-in and check-out times at 21C Museum Hotel Lexington?
Check-in is at 16:00 and check-out is at 11:00.
Are there nearby attractions to visit from 21C Museum Hotel Lexington?
Nearby attractions include the Rupp Arena (0.5 km), Hunt-Morgan House (0.5 km), and the Lexington Convention Center (0.5 km).
What room amenities are provided at 21C Museum Hotel Lexington?
Rooms feature Wi-Fi, air conditioning, a flat-screen TV, a desk, a safety deposit box, and a private bathroom.
What options for breakfast are available at 21C Museum Hotel Lexington?
Guests can enjoy breakfast in their rooms, with a range of options including a children's menu.
Does 21C Museum Hotel Lexington offer business services?
The hotel provides a business center, meeting rooms, and high-speed Wi-Fi for business travelers.
What languages are spoken by the staff at 21C Museum Hotel Lexington?
The staff speaks multiple languages, including English.
What unique features does 21C Museum Hotel Lexington offer?
The hotel integrates contemporary art throughout its spaces and has several temporary art galleries on site.
Are there any special accommodations for guests with disabilities at 21C Museum Hotel Lexington?
The hotel includes accessible amenities and features designed for guests with limited mobility.

Next best alternative

Consider them for your next trip.
Check-in
28Dec2025Select date
Check-out
29Dec2025Select date
Rooms and Guests2 Guests, 1 Room
Need more options?
Check Top hotels near 21C Museum Hotel Lexington
Residence Inn By Marriott Lexington City Center Exterior photo
Mobile-only price

Residence Inn By Marriott Lexington City Center

8.4
Great116 reviews
70m from property
USD 164USD 147
per night
Lexington Marriott City Center Exterior photo
Mobile-only price

Lexington Marriott City Center

8.0
Great100 reviews
111m from property
USD 324USD 291
per night
Hilton Lexington Downtown Hotel Interior photo
Mobile-only price

Hilton Lexington Downtown Hotel

8.1
Great644 reviews
272m from property
USD 92USD 82
per night